Bladder cancer mutations can be detected in urine before diagnosing: WHO

IARC scientists are now collaborating with other large prospective cohort studies to confirm these findings. Image Credit: Twitter(@SAgovnews)

(Discourse on Development) — A new study conducted by researchers from the United Nations health agency revealed that bladder cancer mutations can be detected in urine for up to 10 years before clinically diagnosing the disease.

The test is based on detecting mutations in the telomerase reverse transcriptase (TERT) gene – a crucial element for cancer genesis and progression – the most common mutations in bladder cancer, according to the report conducted by the UN World Health Organization’s (WHO) International Agency for Research on Cancer (IARC) and international partners.

The new evidence is detailed in an article published by The Lancet, which highlights the potential of early detection.

“A simple urine test has recently been developed, and these new results are another exciting step towards the validation of a non-invasive early detection tool,” maintained Florence Le Calvez-Kelm, IARC scientist and principal investigator of the study.

“This test could significantly improve and simplify the way in which bladder cancer is detected.” (…)

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